South Africa, Eswatini and Zambia started Lenacapavir vaccination for HIV

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The World Health Organization (WHO) new guidelines recommend use of injectable lenacapavir (LEN) twice a year as an additional pre-exposure prophylaxis (PrEP) option for HIV prevention, in a landmark policy action that could help reshape the global HIV response. The guidelines are being issued at the 13th International AIDS Society Conference (IAS 2025) on HIV Science, in Kigali, Rwanda.

LEN, administered twice a year as PrEP, has been shown to be highly effective at reducing the risk of HIV acquisition.

As part of these guidelines, WHO has recommended a public health approach to HIV testing using HIV rapid tests to support delivery of long-acting injectable PrEP, including LEN and cabotegravir (CAB-LA). The simplified testing recommendation removes a major access barrier by eliminating complex, costly procedures and enabling community-based delivery of long-acting PrEP through pharmacies, clinics, and tele-health.

WHO reported  96% reduction in the risk of acquiring HIV among study participants, with 99.9% of individuals using LEN not acquiring HIV. Only two new HIV cases were recorded among 2180 participants receiving LEN twice-yearly, compared to nine new cases among the 1087 participants receiving daily oral TDF/FTC (tenofovir disoproxil fumarate/emtricitabine). Lenacapavir demonstrated a 96% reduction in HIV incidence compared to background HIV incidence (2.37 per 100 person-years) and was 89% more effective than daily oral TDF/FTC in preventing HIV acquisition. Both LEN and daily oral TDF/FTC were well tolerated, with no significant or new safety concerns identified.

  1. The Hindu
  2. " Long-acting injectable lenacapavir proves effective in HIV prevention for women " - WHO
  3. " Guidelines on lenacapavir for HIV prevention and testing strategies for long-acting injectable pre-exposure prophylaxis " - WHO
  4. " WHO recommends injectable lenacapavir for HIV prevention " - WHO

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