Nobel Prize in Physiology or Medicine 2023

By

Awarded to:

Katalin Karikó and Drew Weissman

for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19

About mRNA vaccine:

Vaccines help prevent infection by preparing the body to fight foreign invaders (such as bacteria, viruses, or other pathogens). All vaccines introduce into the body a harmless piece of a particular bacteria or virus, triggering an immune response. Most vaccines contain a weakened or dead bacteria or virus. However, scientists have developed a new type of vaccine that uses a molecule called messenger RNA (mRNA) rather than part of an actual bacteria or virus. Messenger RNA is a type of RNA that is necessary for protein production.  Once cells finish making a protein, they quickly break down the mRNA. mRNA from vaccines does not enter the nucleus and does not alter DNA.

mRNA vaccines work by introducing a piece of mRNA that corresponds to a viral protein, usually a small piece of a protein found on the virus’s outer membrane. (Individuals who get an mRNA vaccine are not exposed to the virus, nor can they become infected with the virus by the vaccine.) By using this mRNA, cells can produce the viral protein. As part of a normal immune response, the immune system recognizes that the protein is foreign and produces specialized proteins called antibodies. Antibodies help protect the body against infection by recognizing individual viruses or other pathogens, attaching to them, and marking the pathogens for destruction. Once produced, antibodies remain in the body, even after the body has rid itself of the pathogen, so that the immune system can quickly respond if exposed again. If a person is exposed to a virus after receiving mRNA vaccination for it, antibodies can quickly recognize it, attach to it, and mark it for destruction before it can cause serious illness.

mRNA Vaccines have following challenges:

In vitro transcribed mRNA was considered unstable and challenging to deliver, requiring the development of sophisticated carrier lipid systems to encapsulate the mRNA. Moreover, in vitro-produced mRNA gave rise to inflammatory reactions.

Significance of Research:

The above are the challenges of mRNA vaccine addressed by Researchers.

They showed that including base modification in mRNA had following advantages:

The inflammatory response was almost abolished when base modifications were included in the mRNA.

The delivery of mRNA generated with base modifications markedly increased protein production compared to unmodified mRNA. 

Nobel Prize in Physiology or Medicine 2023

MedlinePlus

Comments

Post a Comment

Popular posts from this blog

Russian parliament passed a bill to revoke its ratification of the Comprehensive Test Ban Treaty

By
Relevance:  Russia revokes ratification of nuclear test ban treaty (CTBT) - ICAN But it affirmed that it will  retain its cooperation with the treaty’s verification system and implementing organisation.  Comprehensive Test Ban Treaty: The Comprehensive Test Ban Treaty (CTBT), which opened for signature in 1996, was intended to prohibit all nuclear weapon test explosions. Over 2,000 nuclear tests occurred between 1945 and 1996: the United States (1,000+), the Soviet Union (700+), France (200+), the United Kingdom and China (45 each). As at January 2013, 183 countries had signed the Treaty, of which 158 have also ratified it, including three of the nuclear weapon states (France, the Russian Federation and the United Kingdom). However, 44 specific nuclear technology holder countries must sign and ratify before the CTBT can enter into force. Of these, eight are still missing: China, Egypt, India , Iran, Israel, North Korea, Pakistan and the US. India , North Korea and Pakista...
Read more

ISRO developing semi-cryogenic engine working on LOX Kerosene propellant

By
ISRO is developing a 2000 kN thrust semi-cryogenic engine working on an LOX Kerosene propellant combination for enhancing the payload capability of LVM3 and for future launch vehicles. Liquid Propulsion Systems Centre (LPSC) is the lead centre for the development of semi-cryogenic propulsion systems with the support of other launch vehicle centres of ISRO. The assembly and testing of the propulsion modules were done at the ISRO propulsion complex (IPRC), Mahendragiri. As part of the engine development, a pre-burner ignition test article, which is a full complement of the engine power head system excluding the turbopumps is realized. The first ignition trial was conducted successfully on May 2, 2024, at semi cryo integrated engine test facility (SIET) at IPRC, Mahendragiri, which was dedicated to the nation recently by the honorable Prime Minister of India. Smooth and sustained ignition of the preburner is demonstrated which is vital for the starting of the semi-cryogenic engine. Semi-c...
Read more

Interstellar space and Interstellar Probes ( Voyager and New Horizons Missions )

By
Interstellar Space: Interstellar space is often called the space between the stars, but more specifically, it’s the region between our Sun’s heliosphere and the astrospheres of other stars. Our heliosphere is a vast bubble of plasma – a gas of charged particles – that spews out of the Sun. This outflow is known as the solar wind. The bubble surrounds the Sun and stretches beyond the planets. Both Voyager spacecraft had to travel more than 11 billion miles (17 billion kilometers) from the Sun in order to cross the edge of the heliosphere. This bubble is moving through interstellar space as the Sun orbits the center of the Milky Way galaxy. As our heliosphere plows through space, it creates a bow wave, like the wave formed by the bow of a ship. Kuiper Belt &  Oort Cloud: The Kuiper Belt is a doughnut-shaped ring of icy objects around the Sun, extending just beyond the orbit of Neptune from about 30 to 55 AU. Similar to the asteroid belt, the Kuiper Belt is a region of leftovers f...
Read more