Self-amplifying mRNA
Self-amplifying mRNA (saRNA) vaccines, which are mRNA vaccines with the added capability of replicating themselves , are being developed as a promising approach for rapid vaccine development and potentially lower doses, with the CDC and other organizations like CEPI actively involved in their development and research. Here's a more detailed explanation: What are saRNA vaccines? Self-amplifying mRNA vaccines leverage the inherent ability of mRNA to replicate within cells, meaning that once the mRNA is introduced, it not only instructs the cell to produce the antigen but also replicates itself, leading to a higher production of the antigen and potentially requiring lower doses of the vaccine. Benefits of saRNA vaccines: Rapid development: saRNA vaccines can be developed quickly, as they can be synthesized using a cell-free system, and the modular design allows for rapid adaptation to new threats. Lower doses: The self-replicative nature of ...